| Autor: |
Woerdenbag, H.J., Merfort, I., Schmidt, T.J., Passreiter, C.M., Willuhn, G., Van Uden, W., Pras, N., Konings, A.W.T. |
| Zdroj: |
Phytomedicine; October 1995, Vol. 2 Issue: 2 p127-132, 6p |
| Abstrakt: |
The effect of the flavones apigenin, luteolin, hispidulin and eupafolin, and of the flavonols kaempferol, quercetin, 6-methoxykaempferol and patuletin from Arnicaspp. on the cytotoxicity of the sesquiterpene lactone helenalin was studied in the human lung carcinoma cell line GLC4 using the microculture tetrazolium (MTT) assay. The tumour cells were exposed to the test compounds for 2h. Helenalin concentrations around its control IC50value, 0.5 μM, were combined with flavonoid concentrations ranging from 0.01 to 20 μM. At non-toxic concentrations, up to 10μM, all flavonoids except kaempferol significantly reduced the helenalin-induced cytotoxicity. Hispidulin and patuletin displayed their modulating effect on helenalin-induced cytotoxicity in the broadest concentration range. The strongest effect was found with 5 and 10μM hispidulin, 0.05 μM quercetin, and 1 μM patuletin, increasing the IC50value of helenalin with circa 40%. No dose-dependency was found in the concentration range tested. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full Text from ScienceDirect