| Autor: |
Locher, Christopher P., Witvrouw, Myriam, De Béthune, Marie-Pierre, Burch, Mark T., Mower, Howard F., Davis, Harry, Lasure, Aleidis, Pauwels, Rudi, De Clercq, Erik, Vlietinck, Arnold J. |
| Zdroj: |
Phytomedicine; January 1996, Vol. 2 Issue: 3 p259-264, 6p |
| Abstrakt: |
Hawaiian medicinal plants commonly used for the treatment of a variety of infections were screened for antiviral activity against human immunodeficiency virus type 1 (HIV-1). Sixty-one extracts derived from seventeen plants were tested for selective viral growth inhibition using the LAI (HTLV-IIIB) isolate. The greatest degree of antiviral activity was observed with aqueous extracts made from the bark of Eugenia malaccensis(L.) and the leaves of Pluchea indica(Less.) which had antiviral selectivity indices (50% cytotoxic concentration/50% effective antiviral concentration) of 109 and 94, respectively. These and other extracts conferred 100% cell protection against viral cytopathic effect when compared with control samples. Methanol and water extracts made from the Pipturus albidus(Gray) leaves and bark also achieved a high selective inhibition of virus replication with very low cytotoxicity. Plant extracts made from Aleurites moluccana(Willd.), Psychotria hawaiiensis(Gray), Clermontia aborescens(Mann), and Scaevola sericea(Forst.) also showed antiviral activity. These data provide a rationale for the characterization of antiviral natural products from these plants and related plant species. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full Text from ScienceDirect