| Autor: |
Trafikowska, U., Sobkowiak, E., Butler, J.A., Whanger, P.D., Zachara, B.A. |
| Zdroj: |
Journal of Trace Elements in Medicine and Biology; July 1998, Vol. 12 Issue: 2 p77-85, 9p |
| Abstrakt: |
The aim of this study was to determine the effect of selenium (Se) supplementation to lactating women on Se concentrations and glutathione peroxidase (GSH-Px) activities in blood components of mothers and breastfed infants and on milk Se levels and Se intake by breast-fed infants. Lactating mothers were supplied for 3 months with 200 μg Se/day in the form of yeast-Se (Y-Se) and sodium selenite. Initial blood and plasma Se levels of all women (n = 67) were 76.6 and 53.2 μg/L, respectively. After 3 months Se concentrations both in whole blood and in plasma from mothers and infants were significantly higher than the initial values. Y-Se exerts a stronger effect than selenite on blood and plasma Se levels. Initial milk Se concentration was 8.9 μg/L and after 1 month in both groups it reached a plateau at 14–16 μg/L. This resulted in an increase of Se intake in breast-fed infants from 6.1 to a plateau of 11–13 μg Se/day. GSH-Px activities in plasma and red cells of Y-Se group increased significantly and reached a plateau after 1 and 2 months, respectively, while in the selenite group the enzyme activities increased steadily throughout the entire period of the study. Selenite exerts a stronger effect on GSH-Px both in maternal and in infant blood components as compared with Y-Se. In milk the GSH-Px activity in the Y-Se group did not change during the study, while in the selenite group after 3 months it increased almost 2-fold compared to the initial value. In conclusion, this study shows that organic Se causes higher Se deposition than did the inorganic form. |
| Databáze: |
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