| Autor: |
Krishnamurthy, Byregowda, Vinaya, Kambappa, S. Prasanna, Doddakunche, Raghava, Byregowda, S. Rangappa, Kanchugarakoppal |
| Zdroj: |
Letters in Drug Design & Discovery; December 2011, Vol. 8 Issue: 10 p988-995, 8p |
| Abstrakt: |
A series of novel 2-methyl-3-(2-(piperazin-1-yl)ethyl)-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one sulfonamide and carboxamide derivatives were synthesized in good yield. The synthesized compounds were characterized by 1H-NMR, FTIR and elemental analysis. All the synthesised compounds were screened for their in vitro antimicrobial activity by agar well diffusion and micro dilution method against standard strains of Gram-positive (Bacillus subtilis MTCC 121, Staphylococcus epidermidis 435), and Gram-negative (Xanthomonas campestris 7903 and Pseudomonas aeruginosa MTCC 7908) bacteria. Compound 7a and compound 8d with dichloro substitution among sulphonamide and carboxamide series respectively showed potent inhibitory activity. |
| Databáze: |
Supplemental Index |
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