| Autor: |
Brunelli, Claudio, Parodi, Oberdan, Sambuceti, Gianmario, Corsiglia, Luca, Rosa, Gian M., Giorgetti, Assuero, Bezante, Gian P., Nista, Nicola, Caponnetto, Salvatore |
| Zdroj: |
Journal of the American College of Cardiology; February 1995, Vol. 25 Issue: 2, Number 2 Supplement 1 p365A-365A, 1p |
| Abstrakt: |
After infarction, regional dysfunction can occur in still viable myocardial regions because of the presence of baseline hypoperfusion. Recent evidence suggests that these areas may maintain a residual perfusion reserve. Aim of this study was to evaluate whether oral Nisoldipine can increase regional myocardial myocardial blood flow (MBF) in dyssynergic but viable myocardium after myocardial infarction. To this purpose, 15 patients with isolated left anterior descending coronary (LAD) stenosis were studied 1 month after first myocardial infarction. Patients underwent F18-deoxiglucose imaging, while MBF was measured, using positron emission tomography and 13-Ammonia, at baseline and following dobutamine (10μcg/kg/min over 5minutes, DOB). MBF measurements were repeated 24hours later after Nisoldipine (10mg bid). Among atotal of 102 LAD related regions, 23 showed normal wall motion at 2D-echo and normal metabolic activity (Normal), 58 showed wall motion abnormality and preserved deoxiglucose uptake (Viable), while 21 dyssynergic regions were necrotic (Necrotic). MBF data (ml/mm/100 g) were as follows:Before NisoldipineAfter NisoldipineBasal MBFDOB MBFBasal MBFDOB MBFNormal92±23119±3885±18121±46°Viable62±25†93±40†,°73±25∧102±51°Necrotic46±24†,@51±25†,@52±20†,@56±2B†,@†p<0.05vs Normal@p<0.05vs Viable°p<005 vo relative Basal∧p<0.05 vo Basal before Nisoldipine |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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