| Autor: |
Waksman, Ron, Robinson, Keith A., Crocker, Ian R., Gravanis, Michael B., Cipolla, Gustavo D., King, Spencer B. |
| Zdroj: |
Journal of the American College of Cardiology; February 1995, Vol. 25 Issue: 2, Number 2 Supplement 1 p287A-287A, 1p |
| Abstrakt: |
Restenosis after balloon angioplasty is characterized by neointima formation. We have previously shown that ionizing radiation reduce neointima formation two weeks after angioplasty in a swine model of restenosis. To determine the durability of this effect and the long term safety after endovascular irradiation twenty one miniswine coronary arteries underwent overstretch balloon injury with a 3.5mm angioplasty balloon in the LAD, LCX and RCA. High energy 1921ridium source was introduced immediately by random assignment to deliver 700 or 1400 cGy in 14 injured coronary arteries (LAD and CX). Six months later an angiogram was performed, the animals were killed and the coronary arteries were perfusion fixed. Serial sections were stained with H&E, WG, MT then evaluated by histopathologic and morphometric techniques. Intimal area (IA) and area of intimal thickness corrected for the extent of injury (INFL) was measured in the irradiated and control arteries and compared with pigs that underwent the same treatment but were followed for 2 weeks only. |
| Databáze: |
Supplemental Index |
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