| Autor: |
Waksman, Ron, Robinson, Keith A., Crocker, Ian R., Gravanis, Michael B., Palmer, Spencer J., Cipolla, Gustavo D., King, Spencer B. |
| Zdroj: |
Journal of the American College of Cardiology; February 1995, Vol. 25 Issue: 2, Number 2 Supplement 1 p287A-287A, 1p |
| Abstrakt: |
Stent implantation has been shown to reduce restenosis by establishing a larger lumen not by reducing neointima formation. We have previously shown that ionizing radiation reduced neointima formation in a swine model of restenosis. The purpose of this study was to determine whether endovascular radiation of the coronary artery prior to stent implantation would affect neointima formation. Five normolipemic pigs underwent coronary angiography; segments of the LAD or the CX were chosen as targets for stenting. A high energy 192lridium source was used to deliver 1400 cGy by random assignment to One of the vessels, then 3.5mm tantalum stents were implantedin both arteries. All animals received aspirin 325mg daily. They were killed at 30 days, and the coronary vasculature perfusion fixed with 10% formalin. The arteries were embedded in methyl methacrylate, and sectioned with the stents in place using a low-speed saw. Serial sections spanning the injury site were ground to 30μm, stained with toluidine blue, then evaluated by histopathologic and morphometric techniques. The maximal intimal thickness (MIT), intimal area (IA), and vessel perimeter (VPI were measured from each section. Student's paired Hest was used for comparison of groups. Stent artery ratio was similar in the radiated artery 1.52±0.55 versus control 1.50±0.33.MIT, mmIA, mm2Vp, mmControl0.9±0.473.64±1.5210.6±1.54Irradiated0.63±0.282.34±1.4810.5±0.62P value0.030.0070.8 |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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