| Autor: |
Dittrich, Howard C., Bales, Gary L., McFerran, Britta A., Kuvelas, Mary T., Hunt, Roberta M. |
| Zdroj: |
Journal of the American College of Cardiology; February 1995, Vol. 25 Issue: 2, Number 2 Supplement 1 p204A-204A, 1p |
| Abstrakt: |
In order for myocardial contrast echocardiography to become clinically useful, ultrasound contrast agents must result in reproducible opacification. We therefore studied a new agent capable of producing myocardial opacification when given intravenously. FS069, proteinaceous, gas-filled microspheres (mean size range: 3.6–5.4 micron, concentration: 6.3–9.0 x 108/m1). was administered to 10 closed-chest anesthetized dogs (20–29 kg) in doses of 0.4–0.7 ml at a rate of 0.3 ml/sec into an internal jugular or cephalic vein. Total volumes/dog were 28–54ml. Transthoracic, parasternal short axis images were acquired using a Hewlett Packard Sonos 1500 and time-intensity curves from gated images were generated from the anterior, septal, and lateral left ventricular walls and cavity with an on-line system. The increase in mean pixel intensity compared to baseline was measured. No changes in heart rate, systemic blood pressure, or arterial blood gases attributable to FS069 were detected. Myocardial opacification in multiple segments was documented in 100% of injections. There was no significant difference in intensity change between injections although there was a difference between myocardial segments within the same injection.Intensity Change (mean ± SD)AnteriorSeptalLateralCavityInjection 1, dB05±0.652±4.62.2±1516.8±66Injection 2, dB0.5±0.64.9±4.52.1±2.416.4±7.01 vs. 2, r0.480.94**0.86*0.99***< 0.01**< 0001 |
| Databáze: |
Supplemental Index |
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