| Autor: |
Ito, Tatsuo, Tanouchi, Jun, Miyawaki, Miwa, Kato, Junji, Morioka, Toshikazu, Nishino, Masami, Iwai, Kunimitsu, Tanahashi, Hideo, Yamada, Yoshio, Abe., Hiroshi |
| Zdroj: |
Journal of the American College of Cardiology; February 1995, Vol. 25 Issue: 2, Number 2 Supplement 1 p193A-193A, 1p |
| Abstrakt: |
Residual viability of infarcted and/or is chemic myocardium is a dominant predictor of long-term prognosis after coronary reperfusion in patients (pts) with acute myocardial infarction (AMI). Viable but dysfunctional myocardium after coronary reperfusion may be assessed with the regional decline of myocardial fatty acid metabolism (FAM) in AMI. 1231-β-methyl-iodophenyl pentadecanoic acid (BMIPP) is a new radionuclide tracer for the evaluation of FAM using SPECT. We assessed residual myocardial viability with the discrepancy between myocardial fatty acid metabolism by rest BMIPP and myocardial perfusion by 201TI (TI) SPECT in 35 pts with AMI after successful revascularization at 3±2 days after the onset. The severity score of both tracers (BMIPP-SS, TI-SS) were calculated as the summation of the defect scores (0=normal to 3=defect) in 9 segments of the left ventricle (LV). LV wall motion score (WMS) and ejection fraction (EF) were evaluated at admission and at 4 weeks after revascularization using cine ventriculography. The WMS on acute stage well correlated with BMIPP-SS (r=0.72, p<0.01). while did not with TI-SS. The BMIPP-SS was significantly larger than the TI-SS (7.8±2.3 vs 4.3±1.8, p<0.01). The discrepancy between BMIPP-SS and TI-SS was significantly correlated with the extent of the improvement of WMS (r=0.81, P<0.01) and EF (r=0.89, P<0.01). We conclude the larger defect in BMIPP than in TI demonstrates the stunned myocardium and the new method is an early predictor for myocardial viability in pts with AMI. |
| Databáze: |
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