| Autor: |
Lombardi, Massimo, Kværness, Jørn, Soma, Johannes, Jones, Richard A., Skjærpe, Terje, Bolz, Klaus-Dieter, Picano, Eugenio, L’Abbate, Antonio, Distante, Alessandro, Rinck, Peter A. |
| Zdroj: |
Journal of the American College of Cardiology; February 1995, Vol. 25 Issue: 2, Number 2 Supplement 1 p12A-12A, 1p |
| Abstrakt: |
To assess the relationship between regional myocardial function, myocardial perfusion pattern and contractile reserve, 12 patients (age 53.5±9.3 years; mean±SD) were studied 4.5 ± 0.9 days after the occurrence of their first Q-wave acute myocardial infarction. Myocardial perfusion was evaluated by an ultrafast gradient echo sequence, implemented on a 0.5 T system for magnetic resonance imaging (MRI). During the acquisition of 64 consecutive, single slice, ECG triggered, diastolic, short axis images of the left ventricle a bolus of gadopentetate (0.05mmol/kg) was injected intravenously. Six regions of interest (ROIs) were drawn on the left ventricle profile of the images and time-intensity curves were obtained. In each patient the time-intensity curve from a region with normal function was used as reference to cross-correlate curves from the other ROIs. A cross-correlation coefficient (CCC), which described the state of myocardial perfusion was obtained for each ROI ranging from 1 (normal perfusion pattern) to 0 (no perfusion). Regional contractile reserve was assessed by 2-D echocardiography at rest and following low dose (up to 10 mcg/kg/min) dobutamine infusion. Out of the 72 regions analysed, 44 segments had normal function and normal perfusion (CCC=0.91±0.13). The remaining 28 regions with resting dyssynergy showed a reduced perfusion (CCC=0.61±0.28; p<0.05 vs normal regions). Perfusion deficit was more marked in the 11 aki-dyskinetic regions than in the 17 hypokinetic regions (CCC=0.35±0.20 vs 0.77±0.20; p <0.05). Out of the 11 regions with severe dyssynergy (resting aki-dyskinesia) the 4 segments showing a functional improvement following dobutamine had a higher perfusion when compared to the 7 segments unresponsive to dobutamine (CCC=0.54±0.1 vs 0.24±0.17; p<0.05). |
| Databáze: |
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