| Autor: |
Vignon, Philippe, Mercury, Paul, Lagrange, Philippe, Lartigue, Martine, Francois, Bruno, Gastinne, Herve |
| Zdroj: |
Journal of the American College of Cardiology; February 1995, Vol. 25 Issue: 2, Number 2 Supplement 1 p12A-12A, 1p |
| Abstrakt: |
Atrial natriuretic factor (ANF) release is augmented by atrial distention whereas positive end-expiratory pressure (PEEP) ventilation has the opposite effect. We tested the hypothesis that PEEP-induced decrease in ANF secretion is mediated by a decrease in right atrial (RA) distention. Accordingly, eight hemodynamically stable mechanically ventilated patients (age: 22-49) in sinus rythm and without kidney or cardiovascular disease were studied. A central venous catheter (3Fr) and a fluid-filled probe were inserted into the RA and esophagus, respectively, in order to measure transmural RA pressure (tP). A radial artery catheter was placed to monitor blood pressure (BP) and withdraw blood samples for the measurement of plasma immunoreactive ANF (irANF). Blood pressure, diuresis, tP, endsystolic RA area at the level of the foramen ovale (acquired using transesophageal echocardiography at end-expiration) and irANF were measured at the end of 3 consecutive 30 min periods of: (1) mechanical ventilation at zero end-expiratory pressure (ZEEP1); (2) application of PEEP +15 cm of H2O; and (3) after withdrawal of the PEEP (ZEEP2). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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