Thematic Analysis™ : A Chemogenomic Approach to GPCR Drug Discovery

Autor: Crossley, Roger, Anne Macritchie, Jacqueline, John Slater, Martin
Zdroj: Current Topics in Medicinal Chemistry; August 2011, Vol. 11 Issue: 15 p1925-1943, 19p
Abstrakt: Thematic Analysis™ is a chemogenomic tool which has been developed and used to aid the process of GPCR drug discovery. This review covers the scientific rationale behind the development of this tool and provides examples of the successful application of the chemogenomic method in both hit finding and hit to lead stages of the drug discovery process.
Databáze: Supplemental Index