| Autor: |
Hervás, Ildefonso, Vilaró, M Teresa, Romero, Luz, Scorza, MCecilia, Mengod, Guadalupe, Artigas, Francesc |
| Zdroj: |
Neuropsychopharmacology; January 2001, Vol. 24 Issue: 1 p11-20, 10p |
| Abstrakt: |
Using microdialysis, receptor autoradiography and in situ hybridization, we examined the effects of fluoxetine alone or with WAY-100635 on: (a) extracellular 5-HT in frontal cortex; and (b) density and sensitivity of 5-HT1Aautoreceptors in rat brain. WAY-100635 (0.3 mg/kg, s.c.) doubled the increase in extracellular 5-HT produced by fluoxetine (3 mg/kg, i.p.) in frontal cortex. Two-week minipump treatments with these daily doses significantly raised extracellular 5-HT to 275 ± 33% (fluoxetine) and 245 ± 10% (fluoxetine plus WAY-100635) of controls. Fluoxetine 3 mg/kg·day desensitized dorsal raphe 5-HT1Aautoreceptors, an effect prevented by the concurrent WAY-100635 administration. However, WAY-100635 (alone or with fluoxetine) did not change 5-HT1Aautoreceptor sensitivity. The density of 5-HT1Areceptors and its encoding mRNA, was unaffected by these treatments. These results suggest that prolonged blockade of 5-HT1Areceptors in vivo prevents the autoreceptor desensitization induced by fluoxetine but does not result in receptor sensitization.Neuropsychopharmacology (2001) 24 11–20.10.1016/S0893-133X(00)00175-5 |
| Databáze: |
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