| Autor: |
Besmer, Peter, Murphy, John E., George, Patricia C., Qiu, Feihua, Bergold, Peter J., Lederman, Lynn, Snyder, Harry W., Brodeur, David, Zuckerman, Evelyn E., Hardy, William D. |
| Zdroj: |
Nature; April 1986, Vol. 320 Issue: 6061 p415-421, 7p |
| Abstrakt: |
A new acute transforming feline retrovirus, the Hardy-Zuckerman 4 feline sarcoma virus (HZ4-FeSV), has been isolated from a feline fibrosarcoma. The viral genome of HZ4-FeSV contains a new oncogene designated v-kit, has the structure 5′ ▵gag-kit-▵pol-▵env 3′ and specifies a gag-kit polyprotein of relative molecular mass 80,000. The predicted kit amino-acid sequence displays partial homology with tyrosine-specific protein kinase oncogenes. HZ4-FeSV appears to have been generated by transduction of feline c-kit sequences with feline leukaemia virus. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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