| Autor: |
Weil, Jon, Epstein, Charles J., Epstein, Lois B., Sedmak, J. James, Sabran, Jan L., Grossberg, Sidney E. |
| Zdroj: |
Nature; February 1983, Vol. 301 Issue: 5899 p437-439, 3p |
| Abstrakt: |
Human immune interferon (IFN-γ) differs from leukocyte interferon (IFN-α) and fibroblast interferon (IFN-β) in cell origin, inducing agents, physical and biological properties1and amino acid sequence2. These differences have led to interest in possible differences in the biological properties of IFN-γ compared with IFN-α and IFN-β. IFN-γ has the same broad range of biochemical and biological actions as do IFN-α and IFN-β, although relative potencies vary depending on the cell type and function investigated3. There has so far been no direct evidence that IFN-γ alters normal cell functions differently from other interferons1,3. We report here striking qualitative and quantitative differences in the intracellular response of human fibro-blasts to IFN-γ compared with IFN-α and IFN-β. Two-dimensional gel electrophoresis demonstrates, in addition to the induction of a common group of polypeptides, the existence of a set of polypeptides whose synthesis is uniquely induced by IFN-γ. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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