| Autor: |
HOGAN, PATRICK G., MARSHALL, JEAN M., HALL, ZACH W. |
| Zdroj: |
Nature; May 1976, Vol. 261 Issue: 5558 p328-330, 3p |
| Abstrakt: |
DURING development of skeletal muscle, and after denervation or reinnervation of adult muscle, there are significant changes in the number of extrajunctional acetylcholine (ACh) receptors, measured both by sensitivity to ACh and by binding of α-125I-bungarotoxin (for review, see ref. 1). Muscle activity has been shown to be a major factor in controlling the level of extrajunctional receptors. Direct electrical stimulation of denervated muscle both in vivoand in vitrodecreases the sensitivity of the extrajunctional membrane to ACh2–5, whereas chronic postsynaptic blockade of innervated muscle in vivoincreases its sensitivity6,7. Muscle activity could alter the level of extrajunctional receptor by changing rates of synthesis or degradation of the receptor. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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