| Autor: |
ALTONA, C., VAN BOOM, J. H., DE JAGER, JENNY, KOENERS, H. J., VAN BINST, G. |
| Zdroj: |
Nature; February 1974, Vol. 247 Issue: 5442 p558-561, 4p |
| Abstrakt: |
THE availability of a large Fourier transform (FT) NMR system in the laboratory of one of us (G. v. B.) allowed us to obtain a series of proton magnetic resonance spectra of nucleosides and dinucleoside monophosphates superior to any hitherto reported. We shall show that the use of the FT-technique at 270 MHz can increase our understanding of the structural features and of the dynamics of the stacking (helix-forming) processes because the chemical shifts as well as the 1H-1H and the 1H-31P coupling constants hidden in the high-field (ribose) part of the spectrum are now in principle amenable to analysis. These parameters provide the key to unlock the secrets of the three-dimensional time-average structure of dinucleosides in solution. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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