| Autor: |
GOTTLIEB, A. ARTHUR, SMITH, ALAN H., PLESCIA, OTTO J., PERSICO, FRANCIS J., NICHOLSON, DIARMUID E. |
| Zdroj: |
Nature; December 1973, Vol. 246 Issue: 5434 p480-482, 3p |
| Abstrakt: |
WE have previously reported the existence of several DNA polymerases in the murine myeloma line, MOPC-21 (refs 1 and 2). Two of these polymerases, which we refer to as R-1 and R-2, are capable of synthesising poly(dT) on a poly(rA)·oligo(dT)12–18template. In this report, we show that the R-1 polymerase shares immunological determinants with the ‘reverse transcriptase’ of the Rauscher murine leukaemia virus (MLV). In addition, we show that mice inoculated with the MOPC-21 myeloma tumour line or the Rauscher-virus-induced MCDV-12 tumour line contain a non-immunoglobulin factor in their sera which specifically inactivates the R-1 polymerase. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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