| Autor: |
MOULD, D. L., DAWSON, A. MCL., RENNIE, J. C. |
| Zdroj: |
Nature; November 1970, Vol. 228 Issue: 5273 p779-780, 2p |
| Abstrakt: |
THE incubation period of scrapie in susceptible animals is extremely long1and its apparently non-viral behaviour is also well known2. Biochemical investigations have usually concentrated on brain tissue when histopathological lesions are maximal3, but it seems important experimentally to locate other sites of active replication. Involvement of lymphocytic tissues has been known for some time4–6and agent distribution in organs of the mouse after peripheral subcutaneous inoculation suggested a pathogenesis in which the agent localized and multiplied in lymphocytic tissue before being disseminated to sites of secondary replication such as neural cells7. A ten-fold multiplication in the spleen was observed within 8 weeks of inoculation. A genetically controlled delay in the time of an early rise in agent concentration in spleen has been reported after intracerebral or intraperitoneal inoculation8,9. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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