| Autor: |
DJORDJEVIC, BOZIDAR, EVANS, RICHARD G., PEREZ, AMAURY G., WEILL, MARGUERITE K. |
| Zdroj: |
Nature; November 1969, Vol. 224 Issue: 5221 p803-804, 2p |
| Abstrakt: |
DNA synthesis can be induced in all stages of the division cycle of mammalian cells by such agents as ultraviolet light1, X-irradiation2and alkylating agents3. This so-called unscheduled DNA synthesis is of low magnitude compared with normal, semi-conservative DNA synthesis4, and has been equated to repair activity in damaged cells. We have observed that significant amounts of 3H-thymidine are incorporated into the DNA of HeLa cells without an extracellular stimulus, and at a time when normal, semi-conservative DNA synthesis does not occur. We report here the results of autoradiographic investigations of this spontaneous unscheduled DNA synthesis and its possible role in normal DNA metabolism. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
