| Autor: |
WHELAN, DONALD T., SCRIVER, CHARLES R., MOHYUDDIN, FAZL |
| Zdroj: |
Nature; November 1969, Vol. 224 Issue: 5222 p916-917, 2p |
| Abstrakt: |
THE discovery of glutamic acid decarboxylase (GAD) in mammalian brain was first reported in 19501,2. The product of this enzyme reaction is gamma-aminobutyric acid (GABA), an important neuroinhibitor3. Because GABA occurs in large amounts in the central nervous system, subsequent interest in GAD emphasized its importance in brain to the exclusion of other tissues. But GABA is also present in significant amounts in human kidney4,5and, because it is normally absent from blood, enzymatic synthesis in situ is the most likely explanation for its presence here. We report that GAD is in fact present in mammalian kidney and to a lesser extent in other tissues outside the central nervous system. |
| Databáze: |
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