| Abstrakt: |
ALTHOUGH human adenovirus types 3 (ref. 1), 7 (ref. 2), 12 (ref. 3), 18 (ref. 4), 14, 16, 21 (unpublished work of M. Pina and M. Green) and 31 (ref. 5) have been shown to be oncogenic in hamsters and, in some cases, mice and rats as well, in vitro transformation has been reported only for “highly oncogenic” types 12 (refs. 6–9) and 18 (unpublished results of Rafajko and Huebner). With primary rat embryo cells and a selective medium containing 0.1 mmolar calcium, a quantitative transformation system has been reported for adenovirus type 12 (ref. 9). It seemed that a similar system for the “weakly oncogenic” adenoviruses would be useful for quantitative studies of transformation by these two groups of adenoviruses, and this communication reports the transformation of rat cells by adenovirus type 3. |
