| Abstrakt: |
MORPHINE, and its chemical congeners with similar pharmacological activity, tend to fall into a common structural pattern. They are generally tertiary nitrogen bases, −NR3, characterized by the usual sp3tetrahedral bonding. The actual base function is performed by the unshared pair of electrons on the nitrogen. They have a centrally located, quaternary carbon atom, and an aryl group or groups attached directly to the central carbon atom, and the central carbon is separated from the nitrogen by a two-carbon chain (sp3bonded). |
