| Autor: |
Lewin, David A., Sheff, David, Ooi, Chean Eng, Whitney, J.Andrew, Yamamoto, Ellen, Chicione, Linda M., Webster, Paul, Bonifacino, Juan S., Mellman, Ira |
| Zdroj: |
FEBS Letters; January 1998, Vol. 435 Issue: 2 p263-268, 6p |
| Abstrakt: |
We describe the cloning, expression, and localization of γ 2-adaptin, a novel isoform of γ-adaptin. The predicted human and mouse γ 2-adaptin proteins are ∼90 kDa and 64.4% and 61.7% identical to γ-adaptin, respectively. γ 2-Adaptin was localized to the Golgi, its localization distinct from γ-adaptin. The membrane association of γ- and γ 2-adaptin could further be distinguished by differential sensitivity to the fungal metabolite brefeldin A, γ 2-adaptin binding being insensitive to drug treatment. Together, these results suggest that γ 2-adaptin plays a role in membrane transport distinct from that played by γ-adaptin. |
| Databáze: |
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