| Autor: |
Motegi, Fumio, Nakano, Kentaro, Kitayama, Chikako, Yamamoto, Masayuki, Mabuchi, Issei |
| Zdroj: |
FEBS Letters; January 1997, Vol. 420 Issue: 2 p161-166, 6p |
| Abstrakt: |
We cloned the myo3+gene of Schizosaccharomyces pombewhich encodes a type-II myosin heavy chain. myo3null cells showed a defect in cytokinesis under certain conditions. Overproduction of Myo3 also showed a defect in cytokinesis. Double mutant analysis indicated that Myo3 genetically interacts with Cdc8 tropomyosin and actin. Myo3 may be implicated in cytokinesis and stabilization of F-actin cables. Moreover, the function of Myo2 can be replaced by overexpressed Myo3. We observed a modest synthetic interaction between Myo2 and Myo3. Thus, Myo2 and Myo3 seem to cooperate in the formation of the F-actin ring in S. pombe. |
| Databáze: |
Supplemental Index |
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