| Autor: |
Edeas, Marvin A, Claise, Catherine, Vergnes, Laurent, Khalfoun, Yacine, Barthelemy, Sophie, Labidalle, Serge, Lindenbaum, Albert |
| Zdroj: |
FEBS Letters; January 1997, Vol. 418 Issue: 1 p15-18, 4p |
| Abstrakt: |
Previously, we demonstrated that ferulate ethyl and tocopherol reduced HIV replication. In this study, we investigate whether the conjugation of both compounds ( O-tocopheryl succinyl O-ethyl ferulate) can increase HIV inhibition. We show here for the first time that O-tocopheryl succinyl O-ethyl ferulate inhibits 80% of HIV replication (HIV-1 acute infection and HIV transmission), inhibits cell lipoperoxidation and prevents cellular glutathione consumption. Compared to ferulate ethyl and tocopheryl succinyl, O-tocopheryl succinyl O-ethyl ferulate inhibits more HIV replication. This may be due in part to the great increase in the lipophilicity of this compound. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Plný text