| Autor: |
Yamamoto, Hisanori, Hanada, Kentaro, Kawasaki, Kiyoshi, Nishijima, Masahiro |
| Zdroj: |
FEBS Letters; January 1997, Vol. 417 Issue: 2 p196-198, 3p |
| Abstrakt: |
Curcumin, the major yellow pigment of turmeric ( Curcuma longa), has strong anti-carcinogenic and anti-inflammatory activities. We examined the effects of curcumin on enzyme activities of the following phospholipases in a cell-free system: G protein-mediated phospholipase D (PLD), phosphatidylinositol-specific phospholipase C, and phospholipase A 2from mouse macrophage-like cell line J774.1 cells, sphingomyelinase from bovine brain, and phosphatidylcholine-phospholipase C from Bacillus cereus. Curcumin inhibited several types of phospholipases, most effectively PLD among those tested. It also inhibited 12- O-tetradecanoylphorbol-13-acetate-induced PLD activation in intact J774.1 cells in a dose-dependent manner. These results suggest that the anti-inflammatory and anti-carcinogenic action of curcumin is partly due to the inhibition of PLD. |
| Databáze: |
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