Protein interactions of SGP, an essential Streptococcus mutansGTPase, revealed by biochemical and yeast two‐hybrid system analyses

Autor: Baev, Didi, Ohk, Seung‐Ho, Kuramitsu, Howard K
Zdroj: FEMS Microbiology Letters; March 2000, Vol. 184 Issue: 2 p149-153, 5p
Abstrakt: SGP, a Streptococcus mutansessential GTPase, plays a role in the stress response of the organism. Recently, we proposed that one of the physiological functions of the SGP is the modulation of the GTP/GDP ratio under different growth conditions. In order to further determine the functions of SGP and its possible interactions with other molecules, we carried out immunoprecipitation, SGP binding, and the yeast two‐hybrid system analyses. These approaches suggest that SGP may oligomerize and such interactions could be important for the function of this regulatory protein.
Databáze: Supplemental Index