| Autor: |
Tessier, Christian, Rossini, Gian-Paolo, Pageaux, Jean-Franc¸ois, Cohen, He´le`ne, Lagarde, Michel, Laugier, Christian, Fayard, Jean-Michel |
| Zdroj: |
FEBS Letters; 1996, Vol. 390 Issue: 3 p311-314, 4p |
| Abstrakt: |
Rat uterine stromal cells (UIII) express pancreatic type PLA2 (PLA2-I) receptor and internalize the enzyme bound to receptors. Here, we investigate the proliferating effect and alterations in binding of PLA2-I. There is a dramatic decline in PLA2-I binding in UIII cells as they progress from a nonconfluent proliferating state (40,000 sites/cell) to a confluent state (1300 sites/cell). Intracellular concentration of PLA2-I changed with the alteration in binding, suggesting that regulation in the PLA2 binding capacity may have important implications in growth control mechanisms. |
| Databáze: |
Supplemental Index |
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