| Autor: |
Kato, Tomohisa, Okazaki, Koei, Murakami, Hiroshi, Stettler, Sophie, Fantes, Peter A., Okayama, Hiroto |
| Zdroj: |
FEBS Letters; January 1996, Vol. 378 Issue: 3 p207-212, 6p |
| Abstrakt: |
We identified the phhl+gene that encodes a MAP kinase as the effector of Wis1 MAP kinase kinase in fission yeast, which is highly homologous with HOG1 of S. cerevisiae. Heterothalic phh1dsiruptant is phenotypically indistinguishable from wis1deletion mutant, both displaying the same extent of partial sterility and enhanced sensitivity to a variety of stress. In phh1disruptant, nitrogen starvation-induced expression of ste11+, a key controller of sexual differentiation, is markedly diminished. Ectopic expression of ste11+effectively restores fertility, but not stress resistance, to the phh1disruptant. These data show that stress signal, mediated by a MAP kinase, is required for efficient start of sexual differentiation. |
| Databáze: |
Supplemental Index |
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