Cloning and sequencing of a human thioredoxin reductase

Autor:	Gasdaska, Pamela Y., Gasdaska, John R., Cochran, Shawn, Powis, Garth
Zdroj:	FEBS Letters; January 1995, Vol. 373 Issue: 1 p5-9, 5p
Abstrakt:	The DNA sequence encoding human placental thioredoxin reductase has been determined. Of the 3826 base pairs sequenced, 1650 base pairs were in an open reading frame encoding a mature protein with 495 amino acids and a calculated molecular mass of 54,171. Sequence analysis showed strong similarity to glutathione reductases and other NADPH-dependent reductases. Human thioredoxin reductase contains the redoxactive cysteines in the putative FAD binding domain and has a dimer interface domain not previously seen with prokaryote and lower eukaryote thioredoxin reductases.
Databáze:	Supplemental Index
Externí odkaz:	Plný text