| Autor: |
Nobuo, Nakanishi, Satoshi, Onozawa, Reiko, Matsumoto, Kinji, Kurihara, Takao, Ueha, Hiroyuki, Hasegawa, Naomi, Minami |
| Zdroj: |
FEBS Letters; January 1995, Vol. 368 Issue: 3 p411-414, 4p |
| Abstrakt: |
Cyclic AMP down-regulates vesicular monoamine transport in PC12 cells and thereby decreased catecholamine reuptake from the extracellular fluid. We examined the effects of protein kinase inhibitors and protein phosphatase inhibitors on this cAMP action. Treatment of cells with a protein kinase inhibitor, K252a, increased vesicular amine transport and cellular amine uptake, thereby antagonizing the regulatory action of cAMP. In contrast, a protein phosphatase inhibitor, okadaic acid, had the opposite effect on the amine transport, i.e. it enhanced the cAMP action. These results suggest the involvement of a protein phosphorylation process in the cAMP-dependent modulation of vesicular monoamine transport. |
| Databáze: |
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