| Autor: |
Irie, Fumitoshi, Jwa Hidari, Kazuya I.-P., Tai, Tadashi, Li, Yu-Teh, Seyama, Yousuke, Hirabayashi, Yoshio |
| Zdroj: |
FEBS Letters; January 1994, Vol. 351 Issue: 2 p291-294, 4p |
| Abstrakt: |
A new class of gangliosides, GT1aα and GQ1bα, were initially identified as cholinergic neuron-specific antigens in bovine brain. These gangliosides have in common α2–6 NeuAc linked to the GalNAc residue in the gangliotetraose core structure. In this study, we have determined the biosynthetic pathways of GT1aα and GQ1bα using rat liver Golgi fraction. The results showed that GT1aα and GQ1bα were synthesized from GD1a and GT1b, respectively, by the action of a GalNAc α2–6 sialyltransferase. It was also demonstrated that these two gangliosides were found to exist as extremely minor components in rat liver. |
| Databáze: |
Supplemental Index |
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