| Autor: |
Luczak, Susan E., Pandika, Danielle, Shea, Shoshana H., Eng, Mimy Y., Liang, Tiebing, Wall, Tamara L. |
| Zdroj: |
Alcoholism: Clinical and Experimental Research; July 2011, Vol. 35 Issue: 7 p1238-1245, 8p |
| Abstrakt: |
Background: A mechanistic model has been proposed for how alcohol‐metabolizing gene variants protect individuals from the development of alcohol use disorders, with heightened sensitivity to alcohol being an early step (endophenotype) in this model. This study was designed to determine whether possession of 2 alcohol‐metabolizing genes variations, the aldehyde dehydrogenase ALDH2*2allele and the alcohol dehydrogenase ADH1B*2allele, was associated with self‐reported sensitivity to alcohol at low doses and at initial use. |
| Databáze: |
Supplemental Index |
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