| Autor: |
Ohta, Shuichi, Hiraki, Yuji, Shigeno, Chohei, Suzuki, Fujio, Kasai, Ryuichi, Ikeda, Toshihiko, Kohno, Hiroaki, Lee, Kaechoong, Kikuchi, Haruki, Konishi, Junji, Bentz, Hanne, Rosen, David M., Yamamuro, Takao |
| Zdroj: |
FEBS Letters; January 1992, Vol. 314 Issue: 3 p356-360, 5p |
| Abstrakt: |
Here we report that bone morphogenetic proteins 2 and 3 (BMP-2 and BMP-3) induced marked expression of c- fosmRNA in a biphasic manner, i.e. the late phase (48 to 60 h) as well as the immediate-early phase (0.5 h), in murine osteoblastic MC3T3-El cells in vitro. The BMP-induced late phase c- fosgene expression was temporally associated with the onset of marked expression of the genes for osteocalcin and alkaline phosphatase, differentiation markers of mature osteoblasts. In contrast, none of TGF-β1, 10% FBS, IGF-I and IGF-II, which induced only the immediate-early c- fosmRNA expression, stimulated the expression of osteocalcin and alkaline phosphatase genes. These data suggest that in osteoblasts BMP-2 and BMP-3 induce the late phase expression of c- fos, which may play a role in transcriptional activation of the genes involved in differentiation of osteoblasts. |
| Databáze: |
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