| Autor: |
Halliwell, Barry, Hu, Miao-Lin, Louie, Samuel, Duvall, Timothy R., Tarkington, Brian K., Motchnik, Paul, Cross, Carroll E. |
| Zdroj: |
FEBS Letters; January 1992, Vol. 313 Issue: 1 p62-66, 5p |
| Abstrakt: |
Nitrogen dioxide (NO* 2) is often present in inhaled air and may be generated in vivo from nitric oxide. Exposure of human blood plasma to NO* 2caused rapid losses of ascorbic acid, uric acid and protein thiol groups, as well as lipid peroxidation and depletions of α-tocopherol, bilirubin and ubiquinol-10. No increase in protein carbonyls was detected. Supplementation of plasma with ascorbate decreased the rates of lipid peroxidation. α-tocopherol depletion and loss of uric acid. Uric acid supplementation decreased rates of lipid peroxidation but not the loss of α-tecopherol. We conclude that ascorbic acid, protein -SH groups, uric acid and α-tocopherol may be important agents protecting against NO* 2in vivo. If these antioxidants are depleted, peroxidation of lipids occurs and might contribute to the toxicity of NO* 2. |
| Databáze: |
Supplemental Index |
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