| Autor: |
A. Perez-Molina, Jose, Mora Rillo, Marta, Suarez-Lozano, Ignacio, L. Casado Osorio, Jose, Teira Cobo, Ramon, Rivas Gonzalez, Pablo, Pedrol Clotet, Enric, Hernando Jerez, Asuncion, Domingo Pedrol, Pere, Royuela, Ana, Barquilla Diaz, Elena, Esteban, Herminia, Gonzalez-Garcia, Juan |
| Zdroj: |
Current HIV Research; October 2010, Vol. 8 Issue: 7 p521-530, 10p |
| Abstrakt: |
Objective: Currently, 12 of the Spanish population is foreign-born, and a third of newly diagnosed HIV- infected patients are immigrants. We determined whether being an immigrant was associated with a poorer response to antiretroviral treatment. Methods: Historical multicenter cohort study of naive patients starting HAART. The primary endpoint was time to treatment failure (TTF) defined as virological failure (VF), death, opportunistic disease, treatment discontinuation (D/C), or missing patient. Secondary endpoints were TTF expressed as observed data (TFO; censoring missing patients) and time to virological failure (TVF; censoring missing patients and D/C not due to VF). A multivariate analysis was performed to control for confounders. Results: A total of 1090 treatment-naive HIV-infected patients (387 immigrants and 703 autochthonous) from 33 hospitals were included. Most immigrants were from Sub-Saharan Africa (28.3) or South-Central America/Caribbean (31). Immigrants were significantly younger (34 y vs 39 y), more frequently female (37.5 vs 24.6), with less HCV coinfection than autochthonous patients (7 vs 31.3). There were no differences in baseline viral load (4.95 Log10 vs 4.98 Log10), CD4 lymphocyte count (193.5/L vs 201.5/L), late initiation of HAART (56.4 vs 56.0), or antiretrovirals used. Cox-regression analysis (HR; 95CI) did not show differences in TTF (0.89; 0.66-1.20), TFO (0.95; 0.66-1.36), or TVF (1.00; 0.57-1.78) between immigrants and autochthonous patients. Losses to follow-up were more frequent among immigrants (17.8 vs 12.1; p0.009). Sub-Saharan African patients and immigrant females had a significantly shorter TTF. Conclusions: The response to HAART among immigrant patients was similar to that of autochthonous patients, although they had a higher rate of losses to follow-up. Sub-Saharan Africans and immigrant females may need particular measures to avoid barriers hindering antiviral efficacy. |
| Databáze: |
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