| Autor: |
Sakuma, Shogo, Endo, Tsuyoshi, Kanda, Takashi, Nakamura, Hideki, Yamasaki, Satomi, Yamakawa, Tomio |
| Zdroj: |
Letters in Drug Design & Discovery; July 2011, Vol. 8 Issue: 6 p496-499, 4p |
| Abstrakt: |
We report the synthesis and evaluation of a novel PPARδ agonist, compound 12a, characterized by a benzisoxazole ring. Compound 12a exhibited a potent human PPARδ transactivation activity (EC50: 0.011 M). Preliminary biological testing suggests that compound 12a has significant HDL-cholesterol elevating effect in an animal model of dyslipidemia. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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