| Autor: |
Malter, J.S., Ray, B.C., Westmark, P.R., Westmark, C.J. |
| Zdroj: |
Current Alzheimer Research; May 2010, Vol. 7 Issue: 3 p200-206, 7p |
| Abstrakt: |
As the mechanisms underlying neuronal development and degeneration become clarified, a number of common effectors and signaling pathways are becoming apparent. Here we describe the identification of A, long considered a pathologic mediator of Alzheimers Disease and Down Syndrome, as similarly over-expressed in the neurodevelopmental disease, Fragile X Syndrome. We also show that mGluR5 inhibitors, currently employed for the treatment of Fragile X, reduce A production in rodent models of Fragile X and AD as well as reduce disease phenotypes including seizures. Thus seemingly disparate neurologic diseases may share a common pathologic instigator and be treatable with a common, currently available class of therapeutics. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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