| Autor: |
Trune, Dennis R., Beth Kempton, J., Kessi, Monica |
| Zdroj: |
The Laryngoscope; November 2000, Vol. 110 Issue: 11 p1902-1906, 5p |
| Abstrakt: |
HypothesisAlthough the glucocorticoid prednisone is the standard therapy for autoimmune sensorineural hearing loss, what this hormone does in the ear to restore hearing is not known. MRL/MpJ‐Faslprautoimmune mice consistently have shown only stria vascularis disease, implying that abnormal ion balances in the endolymph underlie cochlear dysfunction. Previously we have shown that hearing loss in these mice is reversed with prednisolone treatment. This, coupled with the complete lack of cochlear inflammation, suggests that the restoration of hearing with prednisolone is due to its sodium transport function and not to its anti‐inflammatory or immune suppression effects. Therefore the hypothesis of this study was that the mineralocorticoid aldosterone, which only increases sodium transport, would be as effective as prednisolone in reversing autoimmune hearing loss. |
| Databáze: |
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