| Autor: |
Nakayama, Hector, Ferreira, Maria Elena, Arias, Antonieta Rojas de, Bilbao, Ninfa Vera de, Torres, Susana, Schinini, Alicia, Fournet, Alain |
| Zdroj: |
Phytotherapy Research; November 2001, Vol. 15 Issue: 7 p630-632, 3p |
| Abstrakt: |
It was reported previously that 2‐n‐propylquinoline was active against the epimastigote form of Trypanosoma cruzi. The effects of oral treatments with benznidazole and 2‐n‐propylquinoline were evaluated in Balb/c mice infected with T. cruzichronically. The reference drug and 2‐n‐propylquinoline were administered 60 days post‐infection for 30 days at 25 mg/mL. At 35 days post‐treatment, the serological tests (ELISA) of the 2‐n‐ propylquinoline‐treated mice were significantly different from the controls (p= 0.01) and the benznidazole‐treated mice (p= 0.03), while this was not the case at 85 days post‐treatment. These results are encouraging for continuing the investigation of other analogues of 2‐n‐propylquinoline in experimental chronic Chagas' disease. Copyright © 2001 John Wiley & Sons, Ltd. |
| Databáze: |
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