Effect of CYP1A1Gene Polymorphisms on Estrogen Metabolism and Bone Density

Autor: Napoli, Nicola, Villareal, Dennis T, Mumm, Steven, Halstead, Linda, Sheikh, Sharmin, Cagaanan, Manuel, Rini, Giovam Battista, Armamento‐Villareal, Reina
Zdroj: Journal of Bone & Mineral Research; February 2005, Vol. 20 Issue: 2 p232-239, 8p
Abstrakt: In this study, we evaluated the effect of polymorphisms of the CYP1A1gene, linked to hormone‐related cancers, on estrogen metabolism and BMD. We found that variants carrying the Aallele (CA and AA) for the C4887A polymorphism have a significantly higher degree of estrogen catabolism and lower femoral BMD.
Databáze: Supplemental Index