| Autor: |
Mourão, R. H. V., Santos, F. O., Franzotti, E. M., Moreno, M. P. N., Antoniolli, A. R. |
| Zdroj: |
Phytotherapy Research; June 1999, Vol. 13 Issue: 4 p352-354, 3p |
| Abstrakt: |
Kalanchoe brasiliensisComb. (Cassulaceae) extracts from leaves picked before and during plant blooming (extracts 1 and 2, respectively) were tested for their antiinflammatory effect on carrageenin‐induced rat paw oedema and for acute toxicity (LD50). Oral doses of 0.25, 0.5 and 1.0 g/kg of extract 1 significantly inhibited the paw oedema during the first 4 h after injection of 2% carrageenin, while oral doses of 0.5, 1.0 and 2.0 g/kg of extract 2 had no inhibitory activity on the paw oedema induced by carrageenin. The results indicate an antiinflammatory effect of extract 1 and a proinflammatory effect of extract 2. K. brasiliensisextracts 1 and 2 presented no acute toxicity on mice at the doses of 0.25 to 5 g/kg administered intraperitoneally. Copyright © 1999 John Wiley & Sons, Ltd. |
| Databáze: |
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