Autor: |
Eno, A. E., Owo, O. I., Itam, E. H., Konya, R. S. |
Zdroj: |
Phytotherapy Research; June 2000, Vol. 14 Issue: 4 p235-239, 5p |
Abstrakt: |
A crude ethanol extract was prepared from the unripened fruit of Carica papaya. Lethality studies showed a dose‐mortality relationship with an LD50of 325.2 mg/kg in mice administered i.p. Male albino Wistar rats were randomly divided into three batches (15 rats per batch)—renal, DOCA‐salt hypertensives and normotensives. Each batch was further divided into three groups—the untreated, hydrallazine and extract treated groups. The mean arterial blood pressure (MAP) and the heart rate were measured in all groups. From the results, the basal (control) MAP were 93.8 ± 4.5, 175.2 ± 5.1 and 181.3 ± 6.2 mmHg in the normotensive, renal and DOCA‐salt hypertensives, respectively. Both hydrallazine (200 µg/100 g i.v) and extract (20 mg/kg.i.v) produced a significant depression of MAP in all groups (p< 0.01 vs controls), but the extract produced about 28% more depression of MAP than hydrallazine in the hypertensive groups. In another group of rats, the extract failed to depress the MAP in rats pretreated with propranolol, but atropine and noradrenaline pretreatment did not prevent the action of the extract on blood pressure. |
Databáze: |
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