| Autor: |
Kurinenko, B.M, Bulgakova, R.Sh, Davydov, R.E |
| Zdroj: |
FEMS Immunology and Medical Microbiology; June 1998, Vol. 21 Issue: 2 p117-122, 6p |
| Abstrakt: |
By using a rosette formation test the effect of ribonuclease Bacillus intermedius(RNase Bi) on T‐ and B‐lymphocytes in human peripheral blood has been studied in vitro. The RNase effect on T‐lymphocytes depends on its concentration: low concentrations (10−6–10−2μg ml−1) stimulate E‐rosette formation whereas high concentrations (10 μg ml−1) suppress it. The amount of B‐lymphocytes decreases under RNase Bi influence in all concentrations tested. RNase Bi like thymus hormones influence immature lymphocytes (0‐cells) by inducing the surface expression of E‐receptors what leads to rosette formation and, thus, contributes to lymphocyte differentiation. The increase in the amount of active T‐cells which represent the mature cell population also confirms the participation of RNase Bi in T‐rank lymphocytes differentiation processes. The RNase Bi effect on the human lymphocytes depends on its catalytic activity. |
| Databáze: |
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