| Autor: |
Sjunnesson, Håkan, Sturegård, Erik, Grubb, Anders, Willén, Roger, Wadström, Torkel |
| Zdroj: |
FEMS Immunology and Medical Microbiology; March 2001, Vol. 30 Issue: 2 p167-172, 6p |
| Abstrakt: |
Eighteen Dunkin–Hartley guinea pigs and 50 NMRI mice were inoculated with Helicobacter pyloriand the infection followed by culture, histopathology, antibody response, and plasma levels of the acute‐phase proteins albumin, C3, and transferrin for up to 7 weeks. The immune response to H. pylorisurface proteins was studied by an enzyme immunoassay (EIA) and Western immunoblot and the plasma levels of albumin, C3, and transferrin were analyzed by single radial immunodiffusion. Guinea pigs had a more severe gastritis and a higher EIA immune response than NMRI mice. Serum C3 levels were elevated in infected guinea pigs after 3 and 7 weeks indicating a systemic inflammatory response and a possible link between H. pyloriinfection and extragastric manifestations such as vasculitis associated with atherosclerosis. Serum cholesterol levels were analyzed in guinea pigs at 7 weeks and indicated a higher level in H. pylori‐infected than in control animals, but this difference was not statistically significant. |
| Databáze: |
Supplemental Index |
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