| Autor: |
Masuoka, James, Wu, Guangqin, Glee, Pati M., Hazen, Kevin C. |
| Zdroj: |
FEMS Immunology and Medical Microbiology; July 1999, Vol. 24 Issue: 4 p421-429, 9p |
| Abstrakt: |
Cell surface hydrophobicity influences the adhesive properties of the opportunistic fungal pathogen Candida albicans. Hydrophobic proteins are present in the C. albicanscell wall. These proteins were used to generate a polyclonal antiserum and monoclonal antibodies. We characterized three of these monoclonal antibodies (designated 6C5, 5F8 and 5D8) that recognize different hydrophobic cell wall proteins. Initial characterization of the three antigens, and assessment of their distribution among various Candidaspecies was also carried out. Further, pretreatment of germ tube initials with the mAb inhibits binding of these cells to immobilized extracellular matrix. These results suggest that these hydrophobic proteins are involved in C. albicansadhesion events. |
| Databáze: |
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