| Autor: |
Harkany, T., De Jong, G.I., Soós, K., Penke, B., Luiten, P.G.M., Gulya, K. |
| Zdroj: |
Brain Research; November 1995, Vol. 698 Issue: 1-2 p270-274, 5p |
| Abstrakt: |
β-Amyloid(1–42) peptide (βAP(1–42)) was injected into the medial septum of rats. After a 14-day survival time, neuronal alterations in the septal cholinergic and GABAergic systems were visualized by means of histo- and immunocytochemical methods. Neurons insulted by the peptide were primarily choline acetyltransferase-immunoreactive (ir), while only minor effects of βAP(1–42) were observed on parvalbumin-ir interneurons. These results indicate that the changes in intracellular Ca2+ level elicited by βAP(1–42) may contribute to β-amyloid neurotoxicity, and Ca2+-binding proteins may play an important role in the protection against the neurotoxic effects of βAP(1–42). |
| Databáze: |
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