Extracellular guanosine and guanosine-5′-triphosphate increase: NGF synthesis and release from cultured mouse neopallial astrocytes

Autor:	Middlemiss, Pamela J., Gysbers, John W., Rathbone, Michel P.
Zdroj:	Brain Research; April 1995, Vol. 677 Issue: 1 p152-156, 5p
Abstrakt:	Cultures of neonatal mouse cortical astrocytes synthesized NGF mRNA and released immunoreactive NGF (ir-NGF) into the culture medium. Addition of 10 μM guanosine or GTP to the cultures increased ir-NGF release by 6 and 2 fold, respectively, after 24 h, and increased NGF mRNA 6 fold after 4 h and 2–3 fold after 24 h. In contrast, neither adenosine nor ATP (each 1–100 μM) affected either NGF mRNA synthesis or ir-NGF release.
Databáze:	Supplemental Index
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