| Autor: |
Cooper, Robert G., Etheridge, Christopher J., Stewart, Luisa, Marshall, John, Rudginsky, Samantha, Cheng, Seng H., Miller, Andrew D. |
| Zdroj: |
Chemistry - A European Journal; January 1998, Vol. 4 Issue: 1 p137-151, 15p |
| Abstrakt: |
Gene delivery with cationic liposomesformed from the diamine‐lipid DC‐Chol and the neutral lipid DOPE has proven successful. New polyamine analogues of DC‐Chol have been synthesised, formulated into cationic liposomes with DOPE and biologically tested in vitro and in vivo in mouse lung. Cationic liposomes containing the novel DC‐Chol analogue CTAP (shown below) work 100 times more effectively in vivo than DC‐Chol containing liposomes (500 times better than DNA alone) and therefore should be suitable for use in human gene therapy approaches towards lung disorders and other clinical conditions. |
| Databáze: |
Supplemental Index |
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